The Maroons (10-13, 5-9 ODAC) extended their three-point first quarter lead with a 25-point second quarter on their way to a third straight win in the young series between the two schools.
Shenandoah (4-19, 1-13) trailed by just three, 13-10, after one but saw the Maroons score seven additional points than the Hornets in the second before extending their lead by another five points in the third.
RC kept up the pressure in the fourth, outscoring SU 23-14 to coast home to the 24-point win.
Roanoke shot 48 percent to the Hornets 31 percent and had a 42-36 advantage on the glass.
Shenandoah did outscore RC on second chance points, 15-8, but 19 turnovers led to 25 Maroons points.
SU was a 51-43 winner over HU on January 7 in the first meeting of the season between the two schools.